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=<span style="color: DarkSlateGray"><font size="+2">'''The Bangham Lab'''</font><span>= | =<span style="color: DarkSlateGray"><font size="+2">'''The Bangham Lab'''</font><span>= | ||
=<span style="color: DarkGreen">Computational Biology</span>= | =<span style="color: DarkGreen">Computational Biology</span>= | ||
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=Photos, Algorithms and Art= | =Photos, Algorithms and Art= | ||
=Tools and Demonstrations= | =Tools and Demonstrations= | ||
=About= | |||
The Bangham Lab is part of the [http://www.uea.ac.uk/cmp/research/cmpbio UEA D’Arcy Thompson Centre] for computational biology. | |||
Revision as of 18:27, 3 May 2011
The Bangham Lab
Computational Biology
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Genes and growing shapesThe aim is to understand how patterns of gene activity in biological organs influence the developing shape. A key notion is that genes may regulate growth direction independently of growth rate. We formalised our ideas in the Growing Polarised Tissue Framework (ref). To make it easy to develop ideas on the relationship between growth and form we implemented a software package: GFtbox. Using GFtbox one can start with a simple sheet of tissue (the canvas), lay out experimentally observed, or hypothesised, patterns of regulator activity and then grow the canvas in 3D. The final shape can be compared quantitatively with it's biological counterpart - so testing the hypotheses.
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<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="3000"> LabelledCropped GPT Snapdragon 2010-000570-0003 double.png LabelledCropped GPT Snapdragon 2010-000570-0002 triple.png LabelledCropped GPT Snapdragon 2010-000570-0001-Wildtype.png </sgallery> |
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<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="4000"> Arabidopsis_Leaf_ATH8bbg.png </sgallery> |
Working with 3D volume imagesThree dimensional (3D) volume images are key to understanding the development of shape. They are produced by CT X-ray scanners, MRI and PET. However, biological gene activity is monitored using fluorescent probes and so optical methods are used: confocal microscopy and optical projection microscopy. The resulting images are large and are best viewed using software that exploits powerful graphics processors. We implemented VolViewer which is a viewer of choice in the open microscopy environment. |
<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="4000"> Arabidopsis_Leaf_ATH8bbg.png </sgallery> |
Photos, Algorithms and Art
Tools and Demonstrations
About
The Bangham Lab is part of the UEA D’Arcy Thompson Centre for computational biology.